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Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review Rosa DD; Pasqualotto AC; de Quadros M; Prezzi SHBraz J Infect Dis 2004[Aug]; 8 (4): 328-30The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.|Adult[MESH]|Anti-Bacterial Agents/therapeutic use[MESH]|Ceftriaxone/therapeutic use[MESH]|Complement C8/*deficiency[MESH]|Humans[MESH]|Male[MESH]|Meningitis, Meningococcal/diagnosis/drug therapy/*immunology[MESH]|Recurrence[MESH] |