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Development of novel therapies for Huntington s disease: hope and challenge Qin ZH; Wang J; Gu ZLActa Pharmacol Sin 2005[Feb]; 26 (2): 129-42Huntington's disease (HD) is an autosomal dominant neurological disease. It is a fatal neurological disorder affecting 5-10 out of 10,000 people. While there are intensive research efforts focusing on uncovering molecular mechanisms of the pathogenesis of HD, a number of studies have begun to look for effective therapies for HD. There is a large body of encouraging news on novel therapeutic developments. The present paper reviews drugs used for symptomatic treatment of HD and experimental therapies targeting HD molecular pathology.|Amantadine/therapeutic use[MESH]|Animals[MESH]|Cell Transplantation[MESH]|Drugs, Chinese Herbal/therapeutic use[MESH]|Humans[MESH]|Huntingtin Protein[MESH]|Huntington Disease/*drug therapy/genetics/therapy[MESH]|Mutation[MESH]|Neostriatum/cytology[MESH]|Nerve Tissue Proteins/*genetics[MESH]|Neuroprotective Agents/*therapeutic use[MESH]|Nuclear Proteins/*genetics[MESH]|Riluzole/therapeutic use[MESH] |
