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English Wikipedia
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Barrett s oesophagus: the new endoscopic modalities have a future Deviere JGut 2005[Mar]; 54 Suppl 1 (Suppl 1): i33-7Barrett's oesophagus is defined as the replacement of squamous oesophageal epithelium by intestinal metaplasia in the distal oesophagus. It is a fairly frequent complication of gastro-oesophageal reflux disease (GORD): 5-10% of patients with GORD suffer from Barrett's oesophagus. GORD is essential for the development of Barrett's oesophagus.1 Intestinal metaplasia is a premalignant lesion that may further develop into dysplasia and lead to adenocarcinoma of the oesophagus. The latter now accounts for almost 50% of oesophageal cancer cases in western countries, and the largest increase in its incidence was recorded during the past two decades. Patients with Barrett's oesophagus have a 2-25% risk of developing mild to severe dysplasia and a 2-5% risk of having adenocarcinoma: 30-150 times higher than the risk in the general population. Forty to fifty per cent of Barrett's oesophagus patients with severe dysplasia would present adenocarcinoma within 5 years.|Adenocarcinoma/drug therapy/pathology/surgery[MESH]|Barrett Esophagus/drug therapy/pathology/*surgery[MESH]|Esophageal Neoplasms/drug therapy/pathology/surgery[MESH]|Esophagoscopy/methods[MESH]|Esophagus/pathology/surgery[MESH]|Humans[MESH]|Metaplasia/surgery[MESH]|Mucous Membrane/pathology/surgery[MESH]|Photochemotherapy/methods[MESH]|Postoperative Complications/etiology[MESH]|Precancerous Conditions/drug therapy/pathology/surgery[MESH] |
