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NAADP: a new second messenger comes of age Santella LMol Interv 2005[Apr]; 5 (2): 70-2Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca(2+) mobilization in a variety of cell types. Its role in physiological processes is increasingly demonstrated by NAADP increases following cellular stimulation. As a second messenger NAADP shows unique features such as the ability to mobilize Ca(2+) from stores that are physically distinct from those connected to the Ca(2+) channels located in the endoplasmic reticulum, namely, the inositol-1,4,5-trisphosphate and the cyclic-ADP-ribose/ ryanodine receptors. Furthermore, the NAADP-induced self-inactivation mechanism is suggestive of an irreversible binding of NAADP to its putative receptor.|Animals[MESH]|Calcium/metabolism[MESH]|Humans[MESH]|Hydrogen-Ion Concentration[MESH]|NADP/*analogs & derivatives/chemistry[MESH]|Oocytes/metabolism[MESH]|Oscillometry[MESH]|Second Messenger Systems[MESH]|Signal Transduction[MESH]|Starfish[MESH]|Time Factors[MESH] |