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Capacitative calcium entry: sensing the calcium stores Putney JW JrJ Cell Biol 2005[May]; 169 (3): 381-2A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential role in the activation of these channels and may be the long sought sensor of calcium store content.|Animals[MESH]|Calcium Channels/genetics/*metabolism[MESH]|Calcium Signaling/*physiology[MESH]|Calcium-Binding Proteins/genetics/isolation & purification/*metabolism[MESH]|Cell Membrane/*metabolism/ultrastructure[MESH]|Drosophila Proteins/genetics/isolation & purification/*metabolism[MESH]|Humans[MESH]|Membrane Proteins/genetics[MESH]|Neoplasm Proteins/genetics[MESH]|Protein Structure, Tertiary/physiology[MESH]|Stromal Interaction Molecule 1[MESH] |
