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Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor Fuchs SYCancer Biol Ther 2005[May]; 4 (5): 506-8The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncogenic activities and of its inactivation in human cancers is expected to gain an important insight into tumorigenesis.|Animals[MESH]|F-Box Proteins/genetics/*metabolism[MESH]|Humans[MESH]|Mice[MESH]|Proto-Oncogene Proteins c-jun/genetics/metabolism[MESH]|Proto-Oncogene Proteins c-myc/genetics/metabolism[MESH]|Receptors, Notch/genetics/metabolism[MESH]|Tumor Suppressor Proteins/genetics/*metabolism[MESH]|Ubiquitin-Protein Ligases/genetics/*metabolism[MESH] |