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The role of the thymus in the pathogenesis of myasthenia gravis Onodera HTohoku J Exp Med 2005[Oct]; 207 (2): 87-98Myasthenia gravis is an organ-specific autoimmune disease characterized by the production of anti-acetylcholine receptor antibodies. In this review, I describe the pathophysiological importance of the altered chemokine receptor-mediated signaling in the thymus and peripheral blood of myasthenia gravis patients. The epidemiological and clinical features of myasthenia gravis are also discussed.|Animals[MESH]|Autoantibodies/immunology[MESH]|Autoimmune Diseases/epidemiology/etiology/immunology/physiopathology[MESH]|Chemokines/*immunology[MESH]|Humans[MESH]|Models, Biological[MESH]|Myasthenia Gravis/epidemiology/*etiology/physiopathology[MESH]|Receptors, Chemokine/immunology[MESH]|Thymus Gland/*immunology[MESH] |
