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CD4+ regulatory cells as a potential immunotherapy Fehervari Z; Sakaguchi SPhilos Trans R Soc Lond B Biol Sci 2005[Sep]; 360 (1461): 1647-61CD4(+) regulatory T (T(R)) cells represent a unique lineage of thymically generated lymphocytes capable of powerfully suppressing immune responses. A large body of experimental data has now confirmed the key role played by these cells in the maintenance of self-tolerance. Increasingly, the importance of these cells is also being recognized in a host of other clinically relevant areas such as transplantation, tumour immunity, allergy and microbial immunity. Additionally, it is also possible to generate T(R) cells by using a variety of ex vivo experimental approaches. We will focus here on harnessing the suppressive abilities of both these families of regulatory cells and how this should give us access to a potent cell-based immunotherapy appropriate for clinical application.|Forkhead Transcription Factors/*immunology[MESH]|Humans[MESH]|Immunotherapy/*methods[MESH]|Infections/*immunology[MESH]|Neoplasms/*immunology[MESH]|Self Tolerance/*immunology[MESH]|T-Lymphocytes, Regulatory/cytology/*immunology[MESH]|Transplantation Immunology/*immunology[MESH] |
