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Directing transition from innate to acquired immunity: defining a role for IL-6 Jones SAJ Immunol 2005[Sep]; 175 (6): 3463-8Appropriate control of leukocyte recruitment and activation is a fundamental requirement for competent host defense and resolving inflammation. A pivotal event that defines the successful outcome of any inflammatory event is the transition from innate to acquired immunity. In IL-6 deficiency, this process appears defective, and a series of in vivo studies have documented important roles for IL-6 in both the resolution of innate immunity and the development of acquired immune responses. Within this review, particular attention will be given to the regulatory properties of the soluble IL-6 receptor and how its activity may affect chronic disease progression.|*Immunity, Cellular[MESH]|*Immunity, Innate[MESH]|Chronic Disease[MESH]|Humans[MESH]|Interleukin-6/immunology/*physiology[MESH]|Leukocytes/immunology[MESH]|Receptors, Interleukin-6/immunology/physiology[MESH] |
