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The survival kinases Akt and Pim as potential pharmacological targets Amaravadi R; Thompson CBJ Clin Invest 2005[Oct]; 115 (10): 2618-24The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.|Animals[MESH]|Apoptosis/*drug effects[MESH]|Cell Survival/drug effects[MESH]|Humans[MESH]|Inflammation/drug therapy/metabolism[MESH]|Ischemia/drug therapy/*metabolism[MESH]|Neoplasms/drug therapy/*metabolism[MESH]|Phosphorylation/drug effects[MESH]|Protein Kinase Inhibitors/metabolism/*therapeutic use[MESH]|Proto-Oncogene Proteins c-akt/*antagonists & inhibitors/metabolism[MESH]|Proto-Oncogene Proteins c-pim-1/*antagonists & inhibitors/metabolism[MESH]|Signal Transduction/*drug effects[MESH] |
