Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Rheumatoid arthritis as a hyper-endoplasmic-reticulum-associated degradation disease Yamasaki S; Yagishita N; Tsuchimochi K; Nishioka K; Nakajima TArthritis Res Ther 2005[]; 7 (5): 181-6We introduce Synoviolin as a novel pathogenic factor in rheumatoid arthritis (RA). Experimental studies indicate that this endoplasmic reticulum (ER)-resident E3 ubiquitin ligase has important functions in the ER-associated degradation (ERAD) system, an essential system for ER homeostasis. Overexpression of Synoviolin in mice causes arthropathy with synovial hyperplasia, whereas heterozygous knockdown results in increased apoptosis of synovial cells and resistance to collagen-induced arthritis in mice. On the basis of these experimental data, we propose that excess elimination of unfolded proteins (that is, 'hyper-ERAD') by overexpression of Synoviolin triggers synovial cell overgrowth and hence a worsening of RA. Further analysis of the hyper-ERAD system may permit the complex pathomechanisms of RA to be uncovered.|Amino Acid Sequence[MESH]|Animals[MESH]|Apoptosis[MESH]|Arthritis, Experimental/genetics/immunology/prevention & control[MESH]|Arthritis, Rheumatoid/*metabolism/pathology[MESH]|Cell Division[MESH]|Disease Progression[MESH]|Endoplasmic Reticulum/*enzymology/physiology[MESH]|Gene Targeting[MESH]|Heterozygote[MESH]|Homeostasis[MESH]|Humans[MESH]|Hyperplasia[MESH]|Immunity, Innate[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Mice, Transgenic[MESH]|Models, Biological[MESH]|Molecular Sequence Data[MESH]|Protein Denaturation[MESH]|Protein Folding[MESH]|Sequence Alignment[MESH]|Sequence Homology, Amino Acid[MESH]|Synovial Membrane/enzymology/pathology[MESH]|Ubiquitin-Protein Ligases/deficiency/genetics/*physiology[MESH] |
