Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Dicing and slicing: the core machinery of the RNA interference pathway Hammond SMFEBS Lett 2005[Oct]; 579 (26): 5822-9RNA interference (RNAi) is broadly defined as a gene silencing pathway that is triggered by double-stranded RNA (dsRNA). Many variations have been described on this theme. The dsRNA trigger can be supplied exogenously, as an experimental tool, or can derive from the genome in the form of microRNAs. Gene silencing can be the result of nucleolytic degradation of the mRNA, or by translational suppression. At the heart of the pathway are two ribonuclease machines. The ribonuclease III enzyme Dicer initiates the RNAi pathway by generating the active short interfering RNA trigger. Silencing is effected by the RNA-induced silencing complex and its RNaseH core enzyme Argonaute. This review describes the discovery of these machines and discusses future lines of work on this amazing biochemical pathway.|*RNA Interference[MESH]|Animals[MESH]|Catalysis[MESH]|Cytoplasm/metabolism[MESH]|Gene Silencing[MESH]|Genome[MESH]|Humans[MESH]|Models, Biological[MESH]|Models, Genetic[MESH]|Protein Structure, Tertiary[MESH]|RNA, Double-Stranded/*chemistry[MESH]|RNA, Messenger/metabolism[MESH]|RNA, Small Interfering/metabolism[MESH]|RNA/chemistry[MESH]|Ribonuclease H/chemistry[MESH] |
