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Computed tomography studies of lung ventilation and perfusion Hoffman EA; Chon DProc Am Thorac Soc 2005[]; 2 (6): 492-8, 506With the emergence of multidetector-row computed tomography (CT) it is now possible to image both structure and function via use of a single imaging modality. Breath-hold spiral CT provides detail of the airway and vascular trees along with texture reflective of the state of the lung parenchyma. Use of stable xenon gas wash-in and/or wash-out methods using an axial mode of the CT scanner whereby images are acquired through gating to the respiratory cycle provide detailed images of regional ventilation with isotropic voxel dimensions now on the order of 0.4 mm. Axial scanning during a breath hold and gating to the electrocardiogram during the passage of a sharp bolus injection of iodinated contrast agent provide detailed images of regional pulmonary perfusion. These dynamic CT methods for the study of regional lung function are discussed in the context of other methods that have been used to study heterogeneity of lung function.|Animals[MESH]|Humans[MESH]|Lung Diseases/*diagnostic imaging/*physiopathology[MESH]|Mice[MESH]|Pulmonary Circulation/*physiology[MESH]|Pulmonary Ventilation/*physiology[MESH]|Tomography, X-Ray Computed/*methods[MESH]|Xenon Radioisotopes[MESH] |
