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Fine-tuning of immune responses by SLAM-related receptors Bhat R; Eissmann P; Endt J; Hoffmann S; Watzl CJ Leukoc Biol 2006[Mar]; 79 (3): 417-24The modulation of antigen receptor signals is important for a productive immune response. The main function of the recently identified members of the signaling lymphocyte activating molecule (SLAM)-related receptors (SRR) is the fine-tuning of immune cell activation. Disruption of SRR function is the cause for severe immune disorders such as X-linked lymphoproliferative syndrome (XLP), where XLP patients carry a mutation in SLAM-associated protein (SAP) (SH2D1A), an important adaptor molecule for the signal transduction of SRR. Recent data also suggest that SRR may play a role in autoimmune diseases and the function of hematopoietic stem and progenitor cells. Here, we review the current understanding of SRR function in different immune cells.|Animals[MESH]|Antigens, CD/immunology[MESH]|Glycoproteins/*immunology[MESH]|Humans[MESH]|Immune System/*immunology[MESH]|Immunoglobulins/*immunology[MESH]|Intracellular Signaling Peptides and Proteins/*immunology[MESH]|Membrane Glycoproteins/immunology[MESH]|Receptors, Cell Surface[MESH]|Receptors, Immunologic/*immunology[MESH]|Signal Transduction/immunology[MESH]|Signaling Lymphocytic Activation Molecule Associated Protein[MESH]|Signaling Lymphocytic Activation Molecule Family[MESH]|Signaling Lymphocytic Activation Molecule Family Member 1[MESH] |