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BTLA, a new inhibitory B7 family receptor with a TNFR family ligand Zeng C; Wu T; Zhen Y; Xia XP; Zhao YCell Mol Immunol 2005[Dec]; 2 (6): 427-32B and T lymphocyte attenuator (BTLA), identified as an immune inhibitory receptor recently, plays widespread roles on T and B cells. Emerging evidence has generated plentiful information on the mechanisms which BTLA mediates negative regulation in immune responses and involves in a variety of physiological and pathological processes. The exploration of the biological mechanisms and regulation of BTLA will open possibilities on novel therapeutic strategies in immune-related diseases.|Animals[MESH]|Autoimmune Diseases/immunology/metabolism[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Ligands[MESH]|Receptors, Immunologic/chemistry/genetics/*immunology/*metabolism[MESH]|Receptors, Tumor Necrosis Factor/chemistry/genetics/*immunology/*metabolism[MESH]|T-Lymphocytes/cytology/immunology[MESH] |
