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Neurological involvement in patients with rheumatic disease Sofat N; Malik O; Higgens CSQJM 2006[Feb]; 99 (2): 69-79Patients with multi-system rheumatic conditions may have disease affecting the central and peripheral nervous systems. Early assessment is often helpful in averting the development of serious complications, which in some conditions can be prevented by the prompt institution of treatment. We review the spectrum of neurological disease in patients with a rheumatological diagnosis. The wide variety of associated neurological complications is discussed in the context of specific rheumatic conditions, varying from spinal cord involvement in rheumatoid arthritis, to neuropsychiatric involvement in systemic lupus erythematosus and neurological sequelae in vasculitic disorders. We discuss diagnostic criteria and recommended management options (where available), and describe the role of new tools such as functional brain imaging in the diagnosis and monitoring of disease. We also discuss the potential for development of neurological complications from the use of anti-rheumatic drugs.|*Connective Tissue Diseases/complications/diagnosis/drug therapy[MESH]|*Musculoskeletal Diseases/complications/diagnosis/drug therapy[MESH]|*Sarcoidosis/complications/diagnosis/drug therapy[MESH]|*Vasculitis/complications/diagnosis/drug therapy[MESH]|Antirheumatic Agents/adverse effects[MESH]|Humans[MESH]|Immunosuppressive Agents/administration & dosage[MESH] |