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Clostridium difficile-associated disease: new challenges from an established pathogen Sunenshine RH; McDonald LCCleve Clin J Med 2006[Feb]; 73 (2): 187-97Clostridium difficile-associated disease (CDAD) can range from uncomplicated diarrhea to sepsis and even death. CDAD rates and severity are increasing, possibly due to a new strain. Transmission of C difficile occurs primarily in health care facilities via the fecal-oral route following transient contamination of the hands of health care workers and patients; contamination of the patient care environment also plays an important role.|Anti-Bacterial Agents/*therapeutic use[MESH]|Anti-Infective Agents/adverse effects/therapeutic use[MESH]|Clostridioides difficile/isolation & purification/*pathogenicity[MESH]|Clostridium Infections/*diagnosis/*drug therapy/prevention & control[MESH]|Cross Infection/*diagnosis/*drug therapy/prevention & control[MESH]|Diagnosis, Differential[MESH]|Disease Progression[MESH]|Humans[MESH]|Infection Control/methods[MESH]|Risk Factors[MESH] |
