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Molecular pathogenetics of renal cancer Skolarikos AA; Papatsoris AG; Alivizatos G; Deliveliotis CAm J Nephrol 2006[]; 26 (3): 218-31Recent developments in genetics and molecular biology have led to an increased understanding of the pathobiology of renal cancer. Thorough knowledge of the molecular pathways associated with renal cancer is a prerequisite for novel potential therapeutic interventions. Studies are ongoing to evaluate novel anticancer agents that target specific molecular entities. This article reviews current knowledge on the genetics and molecular pathogenesis of sporadic and inherited forms of renal cancer.|Animals[MESH]|Antineoplastic Agents/*administration & dosage[MESH]|Drug Delivery Systems/*methods[MESH]|Gene Expression Regulation, Neoplastic/*drug effects[MESH]|Humans[MESH]|Kidney Neoplasms/*drug therapy/genetics/*metabolism[MESH]|Molecular Biology/trends[MESH]|Neoplasm Proteins/genetics/*metabolism[MESH]|Signal Transduction/*drug effects[MESH] |