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Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis Rege TA; Hagood JSFASEB J 2006[Jun]; 20 (8): 1045-54Thy-1 (CD90) is a 25-37 kDa glycosylphosphatidylinositol (GPI) -anchored glycoprotein expressed on many cell types, including T cells, thymocytes, neurons, endothelial cells, and fibroblasts. Activation of Thy-1 can promote T cell activation, and this role of Thy-1 is reviewed elsewhere. Thy-1 also affects numerous nonimmunologic biological processes, including cellular adhesion, neurite outgrowth, tumor growth, migration, and cell death. In reviewing the nonimmunologic functions of Thy-1, we discuss the phenotype of the Thy-1 null mouse, signaling pathways modulated by Thy-1, the role of the GPI anchor in Thy-1 localization to lipid rafts and signaling, and regulation of Thy-1 expression. Thy-1 is an important regulator of cell-cell and cell-matrix interactions, with important roles in nerve regeneration, metastasis, inflammation, and fibrosis.|Animals[MESH]|Apoptosis[MESH]|Axons/physiology[MESH]|Cell Adhesion[MESH]|Cell Communication[MESH]|Cell Movement[MESH]|Extracellular Matrix/metabolism[MESH]|Fibrosis[MESH]|Humans[MESH]|Mice[MESH]|Neoplastic Processes[MESH]|Nerve Regeneration[MESH]|Thy-1 Antigens/*physiology[MESH]|Tumor Suppressor Proteins/physiology[MESH] |
