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Cell-cell communication in Gram-negative bacteria Welch M; Mikkelsen H; Swatton JE; Smith D; Thomas GL; Glansdorp FG; Spring DRMol Biosyst 2005[Sep]; 1 (3): 196-202Over the last decade or so, a wealth of research has established that bacteria communicate with one another using small molecules. These signals enable the individuals in a population to coordinate their behaviour. In the case of pathogens, this behaviour may include decisions such as when to attack a host organism or form a biofilm. Consequently, such signalling systems are excellent targets for the development of new antibacterial therapies. In this review, we assess how Gram-negative bacteria use small molecules for cell-cell communication, and discuss the main approaches that have been developed to interfere with it.|Cell Communication/*physiology[MESH]|Gram-Negative Bacteria/pathogenicity/*physiology[MESH]|Virulence[MESH] |
