Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Pax5--a critical inhibitor of plasma cell fate Nera KP; Lassila OScand J Immunol 2006[Sep]; 64 (3): 190-9Paired box protein 5 (Pax5) is essential for early B cell commitment as well as for B cell development, and continuous expression of Pax5 is required throughout the B cell lineage to maintain the functional identity of B cells. During B cell activation, Pax5 is downregulated before terminal differentiation into antibody-secreting plasma cells, and enforced expression of Pax5 prevents plasmacytic development. Recently, loss of Pax5 was shown to result in the substantial transition to a plasma cell state, demonstrating a functionally significant role for Pax5 in the regulation of terminal B cell differentiation. Here we elucidate the current understanding about the function of Pax5 as a key inhibitor of plasma cell differentiation.|AICDA (Activation-Induced Cytidine Deaminase)[MESH]|Animals[MESH]|B-Lymphocytes/metabolism/*physiology[MESH]|Cell Differentiation[MESH]|Chickens[MESH]|Cytidine Deaminase[MESH]|Cytosine Deaminase/metabolism[MESH]|Gene Expression Regulation[MESH]|Genes, Regulator[MESH]|Humans[MESH]|Ikaros Transcription Factor[MESH]|Mice[MESH]|PAX5 Transcription Factor/genetics/metabolism/*physiology[MESH]|Plasma Cells/*physiology[MESH]|Trans-Activators/metabolism[MESH]|Transcription Factors/metabolism[MESH]|Transcription, Genetic[MESH] |
