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Deiodinases: implications of the local control of thyroid hormone action Bianco AC; Kim BWJ Clin Invest 2006[Oct]; 116 (10): 2571-9The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein-coupled bile acid receptor 1-mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.|Animals[MESH]|Energy Metabolism/physiology[MESH]|Homeostasis/physiology[MESH]|Humans[MESH]|Iodide Peroxidase/chemistry/*metabolism/physiology[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Protein Conformation[MESH]|Signal Transduction/physiology[MESH]|Thyroid Hormones/*metabolism[MESH] |