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Neuron-astrocyte interactions in the regulation of brain energy metabolism: a focus on NMR spectroscopy Escartin C; Valette J; Lebon V; Bonvento GJ Neurochem 2006[Oct]; 99 (2): 393-401An adequate and timely production of ATP by brain cells is of cardinal importance to support the major energetic cost of the rapid processing of information via synaptic and action potentials. Recently, evidence has been accumulated to support the view that the regulation of brain energy metabolism is under the control of an intimate dialogue between astrocytes and neurons. In vitro studies on cultured astrocytes and in vivo studies on rodents have provided evidence that glutamate and Na(+) uptake in astrocytes is a key triggering signal regulating glucose use in the brain. With the advent of NMR spectroscopy, it has been possible to provide experimental evidence to show that energy consumption is mainly devoted to glutamatergic neurotransmission and that glutamate-glutamine cycling is coupled in a approximately 1 : 1 molar stoichiometry to glucose oxidation, at least in the cerebral cortex. This improved understanding of neuron-astrocyte metabolic interactions offers the potential for developing novel therapeutic strategies for many neurological disorders that include a metabolic deficit.|Animals[MESH]|Astrocytes/*metabolism[MESH]|Brain/*metabolism[MESH]|Cell Communication/*physiology[MESH]|Energy Metabolism/*physiology[MESH]|Glucose/metabolism[MESH]|Humans[MESH]|Magnetic Resonance Spectroscopy/*methods[MESH]|Neurodegenerative Diseases/metabolism[MESH]|Neurons/*metabolism[MESH] |
