Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Pancreas and beta-cell development: from the actual to the possible Murtaugh LCDevelopment 2007[Feb]; 134 (3): 427-38The development of insulin-producing pancreatic beta (beta)-cells represents the culmination of a complex developmental program. Cells of the posterior foregut assume a pancreatic identity, cells within the expanding pancreatic primordia adopt an endocrine fate, and a subset of these precursors becomes competent to generate beta-cells. Postnatally, beta-cells are primarily maintained by self-duplication rather than new differentiation. Although major gaps in our knowledge still persist, experiments across several organisms have shed increasing light on the steps of beta-cell specification and differentiation. Increasing our understanding of the extrinsic, as well as intrinsic, mechanisms that control these processes should facilitate efforts to regenerate this important cell type in humans.|Animals[MESH]|Body Patterning[MESH]|Cell Differentiation[MESH]|Embryonic Stem Cells/cytology/physiology[MESH]|Gene Expression Regulation, Developmental[MESH]|Genes, Homeobox[MESH]|Homeodomain Proteins/genetics/physiology[MESH]|Humans[MESH]|Insulin-Secreting Cells/*cytology/physiology[MESH]|Mice[MESH]|Pancreas/cytology/embryology/*growth & development/physiology[MESH]|Signal Transduction[MESH]|Trans-Activators/genetics/physiology[MESH] |
