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Management of recurrent testicular germ cell tumors Sonpavde G; Hutson TE; Roth BJOncologist 2007[Jan]; 12 (1): 51-61Although front-line chemotherapy cures most men with testicular germ cell tumors, salvage therapy is still important in a small but significant minority. Second-line conventional-dose or high-dose chemotherapy with stem cell rescue may cure 25%-50% of patients. New chemotherapeutic agents, including the taxanes gemcitabine and oxaliplatin, have added to the therapeutic armamentarium. Salvage surgical resection has an important role in selected patients. Cisplatin-refractory patients have a poor prognosis with current therapy, and novel chemotherapeutic and biologic agents need to be discovered for such patients.|Humans[MESH]|Male[MESH]|Neoplasm Recurrence, Local/drug therapy/surgery/*therapy[MESH]|Neoplasms, Germ Cell and Embryonal/drug therapy/surgery/*therapy[MESH]|Prognosis[MESH]|Salvage Therapy/*methods[MESH]|Stem Cell Transplantation[MESH]|Testicular Neoplasms/drug therapy/surgery/*therapy[MESH]|Treatment Outcome[MESH] |
