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Concerted action of associated proteins in the regulation of TRPV5 and TRPV6 Schoeber JP; Hoenderop JG; Bindels RJBiochem Soc Trans 2007[Feb]; 35 (Pt 1): 115-9Ca(2+) is an essential ion in all organisms and many physiological functions in the body rely on the exact maintenance of the Ca(2+) balance. The epithelial Ca(2+) channels TRPV5 [TRP (transient receptor potential) vanilloid 5] and TRPV6 are the most Ca(2+)-selective members of the TRP superfamily and are generally considered as the gatekeepers of Ca(2+) entry across epithelia. TRPV5 is involved in Ca(2+) reabsorption from pro-urine, while TRPV6 has an essential role in intestinal Ca(2+) uptake. These channels are the prime targets of calciotropic hormonal regulation, including vitamin D and parathyroid hormone. In addition, extra- and intra-cellular signalling by associated proteins and Ca(2+) itself play key roles in TRPV5 and TRPV6 regulation. In this paper, we describe the present understanding of the concerted action of calbindin-D(28k), klotho and BSPRY (B-box and SPRY-domain-containing protein) at different levels throughout the epithelial cell to control Ca(2+) influx at the luminal entry gate.|*Gene Expression Regulation[MESH]|Animals[MESH]|Calbindins[MESH]|Calcium Channels/*physiology[MESH]|Calcium/metabolism[MESH]|Cell Membrane/metabolism[MESH]|Glucuronidase/metabolism[MESH]|Humans[MESH]|Ions[MESH]|Klotho Proteins[MESH]|Models, Biological[MESH]|Parathyroid Hormone/metabolism[MESH]|Protein Structure, Tertiary[MESH]|S100 Calcium Binding Protein G/chemistry[MESH]|Signal Transduction[MESH]|TRPV Cation Channels/*physiology[MESH]|Vitamin D/chemistry[MESH] |
