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Cells of the synovium in rheumatoid arthritis B cells Mauri C; Ehrenstein MRArthritis Res Ther 2007[]; 9 (2): 205There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently present antigen to T cells, produce soluble factors, including cytokines and chemokines, and form B cell aggregates in the target organ of rheumatoid arthritis. In this review we analyze the multifaceted role that B cells play in the pathogenesis of rheumatoid arthritis and discuss how this information can be used to guide more specific targeting of B cells for the therapy of this disease.|Animals[MESH]|Antigen-Presenting Cells/immunology[MESH]|Arthritis, Rheumatoid/*immunology[MESH]|Autoantibodies[MESH]|B-Lymphocytes/*immunology[MESH]|Humans[MESH]|Synovial Membrane/*cytology/*immunology[MESH] |
