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Artificial protein sensors Schrader T; Koch SMol Biosyst 2007[Apr]; 3 (4): 241-8Protein recognition by synthetic molecules is a challenging endeavour, since these materials must bind to a large relatively flat surface domain and recognize a unique distribution of amino acid residues of varying charge, size and shape. The most promising routes involve specific metal coordination, epitope-docking on miniature proteins, aptamer selection, nonnatural peptide isosteres, functionalized platforms, secondary structure mimetics, molecular imprinting and receptors embedded in lipid layers.|Aptamers, Peptide/chemistry[MESH]|Lipids/chemistry[MESH]|Metals/chemistry[MESH]|Molecular Structure[MESH]|Peptides/*chemistry[MESH]|Protein Folding[MESH]|Protein Structure, Secondary[MESH]|Protein Structure, Tertiary[MESH]|Proteins/*chemistry[MESH]|Structure-Activity Relationship[MESH] |