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Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts Peterson LF; Boyapati A; Ahn EY; Biggs JR; Okumura AJ; Lo MC; Yan M; Zhang DEBlood 2007[Aug]; 110 (3): 799-805Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.|*Translocation, Genetic[MESH]|Animals[MESH]|Cell Transformation, Neoplastic/*genetics/metabolism[MESH]|Chromosomes, Human, Pair 21/*genetics/metabolism[MESH]|Chromosomes, Human, Pair 8/*genetics/metabolism[MESH]|Core Binding Factor Alpha 2 Subunit/biosynthesis/*genetics[MESH]|Humans[MESH]|Leukemia, Myeloid, Acute/*genetics/metabolism/pathology[MESH]|Mice[MESH]|Oncogene Proteins, Fusion/biosynthesis/*genetics[MESH]|RUNX1 Translocation Partner 1 Protein[MESH]|Transcription, Genetic[MESH] |
