Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Mitochondrial Ca2+ as a key regulator of cell life and death Giacomello M; Drago I; Pizzo P; Pozzan TCell Death Differ 2007[Jul]; 14 (7): 1267-74Mitochondrial Ca(2+) homeostasis is today at the center of wide interest in the scientific community because of its role both in the modulation of numerous physiological responses and because of its involvement in cell death. In this review, we briefly summarize a few basic features of mitochondrial Ca(2+) handling in vitro and within living cells, and its involvement in the modulation of Ca(2+)-dependent signaling. We then discuss the role of mitochondrial Ca(2+) in the control of apoptotic death, focusing in particular on the effects of pro- and anti-apoptotic proteins of the Bcl-2 family. Finally, the potential involvement of Ca(2+) and mitochondria in the development of two diseases, Ullrich muscular dystrophy and familial Alzheimer's disease, is briefly discussed.|Alzheimer Disease/genetics/metabolism/physiopathology[MESH]|Animals[MESH]|Apoptosis/*physiology[MESH]|Calcium Signaling/*physiology[MESH]|Calcium/*metabolism[MESH]|Cell Survival/physiology[MESH]|Humans[MESH]|Mitochondria/*metabolism[MESH]|Mitochondrial Diseases/genetics/metabolism/physiopathology[MESH]|Muscular Dystrophies/genetics/metabolism/physiopathology[MESH]|Proto-Oncogene Proteins c-bcl-2/metabolism[MESH] |
