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Role of functional magnetic resonance imaging in drug discovery Paulus MP; Stein MBNeuropsychol Rev 2007[Jun]; 17 (2): 179-88In this review, we survey the state of the field of functional magnetic resonance imaging (fMRI) as it relates to drug discovery and drug development. We highlight the advantages and limitations of fMRI for this purpose and suggest ways to improve the use of fMRI for developing new therapeutics, with emphasis on treatments for anxiety disorders. Fundamentally, pharmacological studies with standard psychiatric treatments using standardized behavioral probes during fMRI will need to be carried out to determine characteristic brain signatures that could be used to predict whether novel compounds are likely to have specific therapeutic effects.|*Image Processing, Computer-Assisted[MESH]|*Magnetic Resonance Imaging[MESH]|Animals[MESH]|Anti-Anxiety Agents/therapeutic use[MESH]|Anxiety Disorders/drug therapy/physiopathology[MESH]|Arousal/drug effects/physiology[MESH]|Brain/*drug effects/*physiopathology[MESH]|Drug Evaluation[MESH]|Drugs, Investigational/*therapeutic use[MESH]|Humans[MESH]|Mental Disorders/*drug therapy/*physiopathology[MESH]|Nerve Net/drug effects/physiopathology[MESH]|Neuropsychological Tests[MESH]|Oxygen Consumption/*drug effects/*physiology[MESH]|Psychotropic Drugs/*therapeutic use[MESH] |