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Preeclampsia: a view through the danger model Bonney EAJ Reprod Immunol 2007[Dec]; 76 (1-2): 68-74Classical thinking suggests that the immune system undergoes activation on the basis of discrimination between 'self' and 'non-self'. Accordingly, the fetus activates the mother's immune system because the fetus is in part 'non-self'. Thus, successful pregnancy depends on constraint of maternal immunity. Preeclampsia is an outcome of lost constraint. Instead, the danger model suggests that normal pregnancy, regardless of the expression of 'non-self' antigens, does not activate the maternal immune system unless that pregnancy expresses danger signals. Thus, preeclampsia stems from stress or abnormal cell death in pregnancy-related tissues. This compels expression of specific danger signals and potential activation of anti-fetal immunity, which secondarily feeds the syndrome. Study of preeclampsia from this perspective may bring forth novel mechanisms and indicators of vascular and metabolic dysfunction during pregnancy.|Female[MESH]|Fetal Death[MESH]|Fetus/immunology/physiology[MESH]|HELLP Syndrome/*immunology/physiopathology[MESH]|Humans[MESH]|Immune Tolerance[MESH]|Maternal-Fetal Exchange[MESH]|Models, Biological[MESH]|Placenta/*immunology[MESH]|Pre-Eclampsia/*immunology/physiopathology[MESH]|Pregnancy[MESH] |
