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Filaggrin s fuller figure: a glimpse into the genetic architecture of atopic dermatitis Sandilands A; Smith FJ; Irvine AD; McLean WHJ Invest Dermatol 2007[Jun]; 127 (6): 1282-4Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema). The recent publication of a strategy to sequence this difficult gene identifies a spectrum of both prevalent and rare mutations that collectively have a significant impact on susceptibility to atopic disease.|Dermatitis, Atopic/*epidemiology/*genetics[MESH]|Filaggrin Proteins[MESH]|Genetic Predisposition to Disease/epidemiology[MESH]|Humans[MESH]|Intermediate Filament Proteins/*genetics[MESH]|Prevalence[MESH]|Risk Factors[MESH] |
