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DNA photodamage recognition by RNA polymerase II Brueckner F; Cramer PFEBS Lett 2007[Jun]; 581 (15): 2757-60During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure-function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription-coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism.|*DNA Damage[MESH]|DNA Repair[MESH]|DNA/chemistry/metabolism/radiation effects[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Photochemistry[MESH]|Pyrimidine Dimers/chemistry/metabolism[MESH]|RNA Polymerase II/*metabolism[MESH]|Transcription, Genetic[MESH] |