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Diagnostic biomarker of asbestos-related mesothelioma: example of translational research Okio H; Kazu S; Masahiro MCancer Sci 2007[Aug]; 98 (8): 1147-51Mesothelioma is an aggressive tumor arising from the mesothelium, and is usually associated with previous exposure to asbestos. The incubation period of asbestos-related mesothelioma is estimated to be approximately 30-40 years. Once mesothelioma has occurred, there is no effective treatment. So, identification of tumor markers and a method for early diagnosis using such markers are urgently needed. Recently, several enzyme-linked immunosorbent assay systems for Erc/mesothelin have been developed, the reported usefulness of which has been assessed and demonstrated as a diagnostic tool. Asbestos-related mesothelioma should be ascribed as a typical environmental carcinogen. In this review, we will present asbestos-related mesothelioma for the study of problems in environmental carcinogenesis.|Animals[MESH]|Asbestos/*toxicity[MESH]|Biomarkers, Tumor/*analysis[MESH]|Environmental Exposure[MESH]|Enzyme-Linked Immunosorbent Assay[MESH]|GPI-Linked Proteins[MESH]|Lung Neoplasms/*etiology[MESH]|Membrane Glycoproteins/*analysis[MESH]|Mesothelin[MESH]|Mesothelioma/*chemically induced/*etiology[MESH]|Oncogene Proteins/*analysis[MESH]|Peritoneal Neoplasms/*etiology[MESH]|Pleural Neoplasms/*etiology[MESH]|Rats[MESH] |
