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Gallstone disease Marschall HU; Einarsson CJ Intern Med 2007[Jun]; 261 (6): 529-42Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems that is supposed to increase in ageing populations at risk. Aetiology and pathogenesis of cholesterol gallstones still are not well defined, and strategies for prevention and efficient nonsurgical therapies are missing. This review summarizes current concepts on the pathogenesis of cholesterol gallstones with focus on the uptake and secretion of biliary lipids and special emphasis on recent studies into the genetic background.|Adult[MESH]|Cholestasis/metabolism[MESH]|Cholesterol/metabolism[MESH]|Dietary Fats/administration & dosage/adverse effects[MESH]|Female[MESH]|Gallbladder/metabolism/physiopathology[MESH]|Gallstones/*etiology/genetics/metabolism[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Lipid Metabolism[MESH]|Risk Factors[MESH] |
