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Stress management: how cells take control of their transposons Ebina H; Levin HLMol Cell 2007[Jul]; 27 (2): 180-181In this issue of Molecular Cell, Dai et al. (2007) describe their exciting discovery that, in Saccharomyces cerevisiae, the integrase of retrotransposon Ty5 is phosphorylated, and this modification stabilizes the interaction between integrase and Sir4p that directs integration to heterochromatin.|DNA, Fungal/genetics/metabolism[MESH]|Heterochromatin/genetics/metabolism[MESH]|Integrases/genetics/metabolism[MESH]|Models, Biological[MESH]|Phosphorylation[MESH]|Retroelements/*genetics[MESH]|Saccharomyces cerevisiae/*genetics/*metabolism[MESH]|Silent Information Regulator Proteins, Saccharomyces cerevisiae/genetics/metabolism[MESH] |
