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Safety and efficiency of recombinant activated factor VII in postcardiotomy massive hemorrhage Lamarche Y; Demers P; Poirier NC; Robitaille D; Cartier RCan J Cardiol 2007[Aug]; 23 (10): 809-13Postoperative massive hemorrhage is a difficult clinical situation after cardiac surgery. Recombinant activated factor VII (rf-VIIa) can be a useful adjunct to surgical hemostasis and blood product transfusion. Four cases of massive hemorrhage treated with rf-VIIa after complex cardiac surgery are reported. A review of the literature and possible guidelines for the use of rf-VIIa in cardiac surgery are provided.|*Treatment Outcome[MESH]|Adult[MESH]|Aged[MESH]|Cardiac Surgical Procedures/*adverse effects[MESH]|Coagulants[MESH]|Factor VIIa/*therapeutic use[MESH]|Female[MESH]|Hemostasis[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Postoperative Hemorrhage/*drug therapy/etiology/therapy[MESH]|Recombinant Proteins/*therapeutic use[MESH]|Risk Factors[MESH] |
