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The neurobiology and genetics of impulse control disorders: relationships to drug addictions Brewer JA; Potenza MNBiochem Pharmacol 2008[Jan]; 75 (1): 63-75Impulse control disorders (ICDs), including pathological gambling, trichotillomania, kleptomania and others, have been conceptualized to lie along an impulsive-compulsive spectrum. Recent data have suggested that these disorders may be considered addictions. Here, we review the genetic and neuropathological bases of the impulse control disorders and consider the disorders within these non-mutually exclusive frameworks.|Animals[MESH]|Decision Making[MESH]|Disruptive, Impulse Control, and Conduct Disorders/*etiology/genetics[MESH]|Dopamine/physiology[MESH]|Endorphins/physiology[MESH]|Genetics, Population[MESH]|Glutamic Acid/physiology[MESH]|Humans[MESH]|Impulsive Behavior[MESH]|Prefrontal Cortex/physiology[MESH]|Reward[MESH]|Stress, Psychological/complications[MESH]|Substance-Related Disorders/*etiology/genetics[MESH]|gamma-Aminobutyric Acid/physiology[MESH] |
