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Mobility and immobility of chromatin in transcription and genome stability Soutoglou E; Misteli TCurr Opin Genet Dev 2007[Oct]; 17 (5): 435-42Chromatin is increasingly recognized as a highly dynamic entity. Chromosome sites in lower and higher eukaryotes undergo frequent, rapid, and constrained local motion and occasional slow, long-range movements. Recent observations have revealed some of the functional relevance of chromatin mobility. Paradoxically, both the mobility and immobility of chromatin appear to have functional consequences: Local diffusional motion of chromatin is important in gene regulation, but global chromatin immobility plays a key role in maintenance of genomic stability.|Animals[MESH]|Cell Nucleus/*physiology[MESH]|Chromatin/*metabolism[MESH]|Chromosome Positioning[MESH]|Chromosomes/*physiology[MESH]|Gene Expression Regulation[MESH]|Genomic Instability[MESH]|Humans[MESH]|Models, Biological[MESH]|Transcription, Genetic[MESH] |
