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lüll Oncogenic role of nucleophosmin/B23 Yung BYChang Gung Med J 2007[Jul]; 30 (4): 285-93Nucleophosmin/B23 was first identified as a nucleolar protein expressed at higher levels in cancer cells compared to normal cells. Nucleophosmin/B23 has long been thus thought to have a role in tumor formation. With our efforts and others in the last 15 years, nucleophosmin/B23 has proven to have an oncogenic role. In this review, we provide evidence suggesting that nucleophosmin/B23 may be a crucial gene in regulation of cancer growth and discuss how nucleophosmin/B23 can contribute to tumorigenesis.|Animals[MESH]|E2F1 Transcription Factor/genetics[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Humans[MESH]|Neoplasms/*etiology[MESH]|Nuclear Proteins/genetics/*physiology[MESH]|Nucleophosmin[MESH]|Protein Processing, Post-Translational[MESH]|Proto-Oncogene Proteins c-myc/physiology[MESH]|Tumor Suppressor Protein p53/physiology[MESH] |