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Regulatory role of cathepsin D in apoptosis Minarowska A; Minarowski L; Karwowska A; Gacko MFolia Histochem Cytobiol 2007[]; 45 (3): 159-63Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. Cathepsin D can either induce apoptosis in presence of cytotoxic factors, but in certain studies an inhibitory role in apoptosis was also reviewed. Detailed review of involvement of cathepsin D in cell apoptosis is a purpose of this paper.|Animals[MESH]|Apoptosis/*physiology[MESH]|Cathepsin D/*physiology[MESH]|Humans[MESH] |
