Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Nf2/Merlin: a coordinator of receptor signalling and intercellular contact Curto M; McClatchey AIBr J Cancer 2008[Jan]; 98 (2): 256-62This review explores possible mechanisms by which the neurofibromatosis type-2 tumour suppressor Merlin regulates contact-dependent inhibition of proliferation. Starting from an evolutionary perspective, the concurrent emergence of intercellular contacts and proliferation control in multicellular organisms is first considered. Following a brief survey of the molecular and subcellular milieus in which merlin performs its function, the importance of different cellular and biological contexts in defining the function of merlin is discussed. Finally, an integrated model for merlin and the Ezrin, Radixin, and Moesin (ERM) proteins functioning in the regulation of cellular interfaces is proposed.|Actin Cytoskeleton/physiology[MESH]|Animals[MESH]|Cell Communication/*genetics[MESH]|Cell Membrane/physiology[MESH]|Cytoskeleton/physiology[MESH]|ErbB Receptors/metabolism/*physiology[MESH]|Evolution, Molecular[MESH]|Humans[MESH]|Models, Biological[MESH]|Neurofibromin 2/genetics/*physiology[MESH]|Signal Transduction/genetics[MESH] |