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Kinase packing defects as drug targets Crespo A; Fernandez ADrug Discov Today 2007[Nov]; 12 (21-22): 917-23Protein kinases constitute major targets in molecular cancer therapy. The structural conservation of kinases causes specificity problems in most drug inhibitors, often resulting in dangerous side effects. Here we survey recent approaches in drug design that exploit a molecular marker for specificity: the pattern of packing defects. These packing defects are solvent-exposed intramolecular hydrogen bonds that may be protected by drugs upon association. In this light, we review design strategies to achieve paralogue discrimination, to control cross reactivity and to overcome drug resistance induced by target mutations.|*Drug Design[MESH]|Animals[MESH]|Antineoplastic Agents/*pharmacology[MESH]|Benzamides[MESH]|Cross Reactions[MESH]|Drug Resistance, Neoplasm[MESH]|Humans[MESH]|Hydrogen Bonding[MESH]|Imatinib Mesylate[MESH]|Piperazines/adverse effects/pharmacology[MESH]|Protein Kinase Inhibitors/*pharmacology[MESH]|Protein Kinases/*chemistry[MESH]|Pyrimidines/adverse effects/pharmacology[MESH] |