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T-cell death and cancer immune tolerance Lu B; Finn OJCell Death Differ 2008[Jan]; 15 (1): 70-9Cancer patients mount adaptive immune responses against their tumors. However, tumor develops many mechanisms to evade effective immunosurveillance. T-cell death caused by tumor plays a critical role in establishing tumor immunotolerance. Chronic stimulation of T cells by tumors leads to activation-induced cell death. Abortive stimulation of T cells by tolerogenic antigen-presenting cells loaded with tumor antigens leads to autonomous death of tumor-specific T cells. Therapeutic approaches that prevent T-cell death in the tumor microenvironment and tumor draining lymph nodes, therefore, should boost adaptive immune responses against cancer.|*Apoptosis[MESH]|*Immune Tolerance[MESH]|*Immunologic Surveillance[MESH]|*Tumor Escape[MESH]|Antigens, Neoplasm/immunology[MESH]|Autophagy[MESH]|Dendritic Cells/immunology[MESH]|Humans[MESH]|Immunity, Cellular[MESH]|Immunotherapy[MESH]|Neoplasms/*immunology/pathology/physiopathology/therapy[MESH]|Suppressor Factors, Immunologic/physiology[MESH]|T-Lymphocyte Subsets/*immunology/physiology[MESH] |
