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Intracellular machinery for the transport of AMPA receptors Esteban JABr J Pharmacol 2008[Mar]; 153 Suppl 1 (Suppl 1): S35-43AMPA-type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors reach their synaptic targets after a complicated journey involving multiple transport steps through different membrane compartments. This review summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity.|Animals[MESH]|Biological Transport, Active/*physiology[MESH]|Cytoskeleton/metabolism[MESH]|Endoplasmic Reticulum/metabolism[MESH]|Humans[MESH]|Long-Term Potentiation/physiology[MESH]|Neuronal Plasticity/physiology[MESH]|Receptors, AMPA/*metabolism[MESH]|Substrate Specificity[MESH]|Synapses/*physiology[MESH] |
