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Bifunctional chelates for metal nuclides Brechbiel MWQ J Nucl Med Mol Imaging 2008[Jun]; 52 (2): 166-73The use of ''non-standard'' metallic radionuclides continues to be an expanding field of investigation. Radiolabeling small molecules, peptides, proteins, and up to nano-particles are all areas of active investigation for both diagnostic and therapeutic applications. All require a common variableaethe need for appropriate chelation chemistry for adequate sequestration of the metallic radionuclide that is equal to the intended application. A brief overview of the array of the chelation chemistry options available to researchers and the means for their selection is provided.|Chelating Agents/*chemistry[MESH]|Isotope Labeling/methods[MESH]|Metals/*chemistry[MESH]|Positron-Emission Tomography/methods[MESH]|Radioisotopes/*chemistry[MESH]|Radiopharmaceuticals/chemistry[MESH] |
