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Ubiquitin domain proteins in disease Madsen L; Schulze A; Seeger M; Hartmann-Petersen RBMC Biochem 2007[Nov]; 8 Suppl 1 (Suppl 1): S1The human genome encodes several ubiquitin-like (UBL) domain proteins (UDPs). Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome system, an essential pathway for protein degradation in eukaryotic cells. Despite their structural similarity, the UBL domains appear to have a range of different targets, resulting in a considerable diversity with respect to UDP function. Here, we give a short summary of the biochemical and physiological roles of the UDPs, which have been linked to human diseases including neurodegeneration and cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).|Animals[MESH]|Disease Models, Animal[MESH]|Gene Targeting/methods[MESH]|Humans[MESH]|Nervous System Diseases/drug therapy/genetics/*metabolism[MESH]|Protein Structure, Tertiary/genetics[MESH]|Ubiquitin/*chemistry/*genetics/metabolism[MESH] |
