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Endothelium-specific gene and stem cell-based therapy for erectile dysfunction Strong TD; Gebska MA; Burnett AL; Champion HC; Bivalacqua TJAsian J Androl 2008[Jan]; 10 (1): 14-22Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.|*Endothelium, Vascular[MESH]|*Genetic Therapy[MESH]|*Stem Cell Transplantation[MESH]|Animals[MESH]|Cell Differentiation[MESH]|Endothelial Cells[MESH]|Erectile Dysfunction/*therapy[MESH]|Humans[MESH]|Male[MESH]|Multipotent Stem Cells/transplantation[MESH]|Nitric Oxide Synthase Type III/genetics[MESH]|Superoxide Dismutase/genetics[MESH]|Vascular Endothelial Growth Factor A/genetics[MESH] |
