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Malignant transformation of multiple familial trichoepithelioma: case report and literature review Lee KH; Kim JE; Cho BK; Kim YC; Park CJActa Derm Venereol 2008[]; 88 (1): 43-6Patients with the autosomal-dominant form of multiple familial trichoepithelioma develop numerous tumours on the face, neck and upper trunk, beginning in childhood. Malignant transformation of such lesions is quite rare; only one case of "malignant trichoepithelioma" has been reported previously, inferring pilomatrix carcinoma on a histological observation. We report here the case of a patient who developed a malignant neoplasm in a long-standing trichoepithelioma lesion on her buttock. Histopathology revealed a transformation zone between the trichoepithelioma and a malignant tumour mass. This case also showed several features of a malignant neoplasm of trichoblastic origin.|*Cell Transformation, Neoplastic[MESH]|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Carcinoma, Skin Appendage/genetics/*pathology[MESH]|Female[MESH]|Hair Follicle/pathology[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Prognosis[MESH]|Skin Neoplasms/genetics/*pathology[MESH] |
